Osimert contains osimertinib and should be taken exactly as prescribed by the treating healthcare professional.
For approved adult indications in the current U.S. labeling, osimertinib is administered orally once daily, and the 80 mg dose can be taken with or without food.
Taking the tablet
Patients should follow the product-specific instructions supplied with their medicine. The tablet should not be altered in a way that conflicts with the applicable prescribing information.
For patients who cannot swallow tablets, the U.S. label describes dispersing the tablet in non-carbonated water without crushing it, followed by immediate administration. Specific preparation volumes differ according to whether oral or nasogastric administration is being used, so the applicable prescribing information should be followed.
Take it consistently
Taking the medicine around the same time each day can help maintain a consistent routine. It should not be taken more frequently or in a larger amount than prescribed.
Missed dose
If a dose is missed, the current U.S. prescribing information states that the missed dose should not be made up; the next dose should be taken at the scheduled time.
Do not change treatment independently
Patients should not stop osimertinib, double a dose, or change the schedule because of side effects without discussing the situation with their healthcare team. Dose interruptions and reductions are used clinically for certain adverse reactions.
Monitoring while taking osimertinib
Monitoring may include assessment of symptoms, laboratory testing, ECG evaluation or cardiac assessment when clinically appropriate. Patients with relevant cardiac risk factors may require left ventricular ejection fraction monitoring.
Seek medical attention for concerning symptoms
Patients should promptly report symptoms such as:
- New or worsening shortness of breath
- New cough or fever
- Fainting or significant palpitations
- Swelling or unexplained rapid weight gain
- New eye pain, redness or visual changes
- Severe blistering or peeling skin
- Unusual bleeding or bruising
- Severe or persistent diarrhea
Storage
Follow the storage instructions printed on the specific product packaging and official product information. Keep medicines out of reach of children.